Menu

Tacrolimus-induced nephrotoxicity in tubuloids

Tacrolimus (TAC) is a first-line immunosuppressant used to prevent rejection after solid-organ transplantation, yet its clinical utility is limited by nephrotoxicity, which can progress to irreversible kidney injury or graft loss. The molecular mechanisms underlying TAC-induced nephrotoxicity remain insufficiently understood. Here, we systematically assessed TAC responses across human in vitro nephron model: adult-stem cell derived kidney organoids.

Details
Type
study
Internal ID
S-VHPS25
Release date
2026-03-18
Version
—
License
CC0
URL
https://www.ebi.ac.uk/biostudies/studies/S-VHPS25
DOI
10.6019/S-VHPS25
Files

No files listed.

Authors
Funding

No funding information available.

No biological model information available.

No chemical information available.

No exposure information available.

Coming soon: normalization, model fitting, statistics, QC, etc.

No linked publications available.

Loading dataset citation…

Case Study: Kidney Regulatory Question: Q2 Flow Step: AOP