Tacrolimus-induced nephrotoxicity in proximal tubule cells sorted from iPSC-derived kidney organoids

Tacrolimus (TAC) is a first-line immunosuppressant used to prevent rejection after solid-organ transplantation, yet its clinical utility is limited by nephrotoxicity, which can progress to irreversible kidney injury or graft loss. The molecular mechanisms underlying TAC-induced nephrotoxicity remain insufficiently understood. Here, we systematically assessed TAC responses across human in vitro nephron model: proximal tubule cells sorted from iPSC-derived kidney organoids.

Details

Type: study
Internal ID: S-VHPS24
Release date: 2026-03-18
Version: —
License: CC-BY
URL: https://www.ebi.ac.uk/biostudies/studies/S-VHPS24
DOI: 10.6019/S-VHPS24

Publications

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Authors

Kate Liang
University Medical Center Utrecht
0009-0001-0965-4436
Anne Metje van Genderen
Utrecht University
0000-0001-9643-7722

Funding

[DRAFT] Dutch Research Agenda (NWA)
[DRAFT] 1292.19.272

[DRAFT] Proximal tubule cells sorted from iPSC-derived kidney organoids

RRID: [DRAFT] CVCL_xxxx · Supplier: [DRAFT] specify iPSC line donor / source

Homo sapiens · Kidney · Proximal tubule · [DRAFT] iPSC-derived sorted proximal tubule cells

Tacrolimus

CAS: 109581-93-3
PubChem: CID 445643

[draft] single / repeated / chronic — specify exposure

Duration: [DRAFT] specify [DRAFT] hours / days

Exposure concentration: [DRAFT] specify range [DRAFT] µM

Bioassays

[DRAFT] Cytotoxicity / nephrotoxicity assay (specify) BAO

Measured: [DRAFT] specify · Readout: [DRAFT] specify ([DRAFT] specify) · Time point: [DRAFT] specify [DRAFT] hours / days · Replicates: [DRAFT] specify number

AOP Linkage

Calcineurin inhibitor induced nephrotoxicity leading to kidney failure

Coming soon: normalization, model fitting, statistics, QC, etc.

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Kidney Question 2: Tacrolimus toxicity Toxicodynamics

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