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Tacrolimus-induced nephrotoxicity in proximal tubule cells sorted from iPSC-derived kidney organoids

Tacrolimus (TAC) is a first-line immunosuppressant used to prevent rejection after solid-organ transplantation, yet its clinical utility is limited by nephrotoxicity, which can progress to irreversible kidney injury or graft loss. The molecular mechanisms underlying TAC-induced nephrotoxicity remain insufficiently understood. Here, we systematically assessed TAC responses across human in vitro nephron model: proximal tubule cells sorted from iPSC-derived kidney organoids.

Details
Type
study
Internal ID
S-VHPS24
Release date
2026-03-18
Version
—
License
CC0
URL
https://www.ebi.ac.uk/biostudies/studies/S-VHPS24
DOI
10.6019/S-VHPS24
Files

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Authors
Funding

No funding information available.

No biological model information available.

No chemical information available.

No exposure information available.

Coming soon: normalization, model fitting, statistics, QC, etc.

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Case Study: Kidney Regulatory Question: Q2 Flow Step: AOP